Cancer Quiz
1. A set of cells in the intestinal epithelium divides continually in order to replace dead cells. A microscopic examination of this population of cells would show that most of them
ARE IN INTERPHASE
2. Mature nerve cells, which are incapable of cell division, are most likely in
G1
3. How does a nucleus in G2 differ from a nucleus in G1?
THE G2 NUCLEUS HAS DOUBLE THE AMOUNT OF DNA AS THE G1 NUCLEUS
4. Cyclin-dependent kinases (Cdk’s) catalyze the phosphorylation of targeted proteins, a process that
CHANGES THE SHAPE AND FUNCTION OF THE TARGETED PROTEINS
5. Regulation of the cell cycle is dependent on cyclins and cyclin-dependent kinases. They key that allows a cell to progress beyond the restriction point is
PHOSPHORYLATION OF RB BY CDK
6. An environment change that leads to the production of less than the expected amount of cyclin would tend to ___ the activity of the Cdk. This would lead to ____ phosphorylation of the target protein, which in turn would lead to ____ cells being stopped at the checkpoint.
DECREASE; DECREASED; MORE
7. The process of programmed cell death is called
APOPTOSIS
8. Which of the following statements about benign tumors is true?
THEY ARE NOT CANCEROUS
9. People who develop the hereditary form of retinoblastoma inherit:
A SINGLE RECESSIVE ALLELE CAUSING RETINOBLASTOMA
10. Which of the following mutations is most likely to result in cell overgrowth and (eventually) may lead to cancer?
A GAIN-OF-FUNCTION MUTATION IN ONE ALLELE OF A PROTO-ONCOGENE